Low Dose Naltrexone (LDN)

In certain clinical situations, I will implement low dose naltrexone (LDN) into my patient’s treatment plan.

This isn’t a band-aid or masking symptoms, it is modulating the immune system.  Here’s how the medication works...

LDN transiently blocks opioid receptors for a few hours, leading to a rebound increase in endogenous endorphins and enkephalins. This modulates immune function. It also acts as toll-like receptor 4 (TLR4) antagonist on microglia, reducing neuroinflammation and downstream cytokine signaling. 

Off label uses:

-Hashimoto’s thyroiditis

 -Graves’ disease

 -Rheumatoid arthritis

 -Systemic lupus erythematosus

 -Multiple sclerosis

 -Inflammatory bowel disease (Crohn’s, ulcerative colitis)

 -Psoriasis

 -Fibromyalgia and chronic fatigue syndrome

Potential side effects:

-Vivid dreams

-GI upset 

*May be an adjustment phase in the first 1-2 weeks. 

*Opioid use is an absolute contraindication. 

Duration:

This is at the discretion of the provider, but can often times be safely used long-term. 

When are results felt?

I have seen as soon as 3 weeks, but I usually say give it 2 months if being used for pain or inflammation.   Depending on the goals and what it is being used for, the patient may not FEEL results. 

Final thoughts:

I always use this as supportive therapy, to give us synergistic effects while we address all the components of life-style and underlying drivers of inflammation. 

As always, work with a trained Provider who can analyze all elements of your clinical picture.